Etymology
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agonist (n.)

1876, in writings on Greek drama, "a hero (attacked in the play by an antagonist)," from Latin agonista, Greek agonistes "rival combatant in the games, competitor; opponent (in a debate)," also, generally "one who struggles (for something)," from agonia "a struggle for victory" (in wrestling, etc.), in a general sense "exercise, gymnastics;" also of mental struggles, "agony, anguish" (see agony). Agonistes as an (ironic) epithet seems to have been introduced in English by T.S. Eliot (1932).

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Definitions of agonist

agonist (n.)
the principal character in a work of fiction;
Synonyms: protagonist
agonist (n.)
someone involved in a contest or battle (as in an agon);
agonist (n.)
a muscle that contracts while another relaxes;
when bending the elbow the biceps are the agonist
agonist (n.)
(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction;
From wordnet.princeton.edu