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U

for historical evolution, see V. Used punningly for you by 1588 ["Love's Labour's Lost," V.i.60], not long after the pronunciation shift that made the vowel a homonym of the pronoun. As a simple shorthand (without intentional word-play), it is recorded from 1862. Common in business abbreviations since 1923 (such as U-Haul, attested from 1951).

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Definitions of U from WordNet

u (n.)
a base containing nitrogen that is found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine;
Synonyms: uracil
u (n.)
a heavy toxic silvery-white radioactive metallic element; occurs in many isotopes; used for nuclear fuels and nuclear weapons;
Synonyms: uranium / atomic number "
From wordnet.princeton.edu