fatal inherited disorder, 1907, named in German (1901) by German neurologist Henryk Higier (1866-1942) from names of British ophthalmologist Warren Tay (1843-1927) and U.S. physician and neurologist Warren Sachs (1858-1944) who had independently described it in 1881 and 1887 respectively.

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Definitions of Tay-Sachs from WordNet

Tay-Sachs (n.)
a hereditary disorder of lipid metabolism occurring most frequently in individuals of Jewish descent in eastern Europe; accumulation of lipids in nervous tissue results in death in early childhood;
Synonyms: Tay-Sachs disease / Sachs disease / infantile amaurotic idiocy