Etymology
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Soho

district in New York city, 1969, from "South of Houston Street," but probably also echoing the name of the London neighborhood (famous for vice by early 19c.), which was so called at least since 1630s, originally "So Ho," a hunting cry (c. 1300) used in calling from a distant place to alert hounds and other hunters; the West End district was so called from earlier association of this area with hunting.

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Definitions of Soho
1
Soho (n.)
a city district of central London now noted for restaurants and nightclubs;
2
SoHo (n.)
a district in southwestern Manhattan noted for its shops and restaurants and galleries and artist's lofts;
Synonyms: South of Houston
From wordnet.princeton.edu