Etymology
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smallpox (n.)

acute, highly contagious disease, 1510s, small pokkes, as distinguished from great pox "syphilis;" from small-pock "pustule caused by smallpox" (mid-15c.); see small (adj.) + pox. Compare French petite vérole. Fatal in a quarter to a third of unvaccinated cases.

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Definitions of smallpox

smallpox (n.)
a highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars;
Synonyms: variola / variola major
From wordnet.princeton.edu