Words related to -cule

word-forming element meaning "small, little" (in capsule, module, etc.), from French -ule, from Latin diminutive suffix -ulus (fem. -ula, neuter -ulum), from PIE *-(o)lo-, from *-lo-, secondary suffix forming diminutives, which also is the source of the first element in native diminutive suffix -ling.
corpuscle (n.)

1650s, "any small particle," from Latin corpusculum "a puny body; an atom, particle," diminutive of corpus "body" (from PIE root *kwrep- "body, form, appearance"); for ending see -cule. In anatomy, "a microscopic body regarded by itself" (1741); applied to blood cells by 1845 (short for blood-corpuscle). Related: Corpuscular.

molecule (n.)

1794, "extremely minute particle," from French molécule (1670s), from Modern Latin molecula, diminutive of Latin moles "mass, barrier" (see mole (n.3)). For ending see -cule. It has a vague meaning at first; the vogue for the word (used until late 18c. only in Latin form) can be traced to the philosophy of Descartes. First used of Modern Latin molecula in modern scientific sense ("smallest part into which a substance can be divided without destroying its chemical character") is by Amedeo Avogadro (1811).

tentacle (n.)
1762, from Modern Latin tentaculum, literally "feeler," from Latin tentare "to feel, try" + -culum, diminutive suffix (see -cule). Related: Tentacular.