early 13c., in frere menour "Franciscan friar," literally "minor friar," from Latin minor "less, lesser, smaller, junior," figuratively "inferior, less important," which was formed as a masculine/feminine form of minus on the mistaken assumption that minus was a neuter comparative, from PIE root *mei- (2) "small." Compare minor (n.). In some cases the English word is from Old French menor "less, smaller, lower; underage, younger," from Latin minor.
Meaning "underage" is from 1570s. Meaning "lesser or smaller (than the other)" in English is from early 15c.; that of "comparatively less important" is from 1620s. The musical sense is from 1690s in reference to intervals (and to tonalities and scales characterized by a minor third), so called because the interval is lesser or shorter than the corresponding major interval. Of triads or chords by 1797; their emotional effect is notable mournful, mysterious, gloomy, or wistful, hence figurative and extended senses. In the baseball sense, minor league, made up of teams below the major league, is from 1884; the figurative extension of that is recorded by 1926.
1726, "morbid longing to return to one's home or native country, severe homesickness considered as a disease," Modern Latin, coined 1688 in a dissertation on the topic at the University of Basel by scholar Johannes Hofer (1669-1752) as a rendering of German heimweh "homesickness" (for which see home + woe).
From Greek algos "pain, grief, distress" (see -algia) + nostos "homecoming," from neomai "to reach some place, escape, return, get home," from PIE *nes- "to return safely home" (cognate with Old Norse nest "food for a journey," Sanskrit nasate "approaches, joins," German genesen "to recover," Gothic ganisan "to heal," Old English genesen "to recover"). French nostalgie is in French army medical manuals by 1754.
Originally in reference to the Swiss and said to be peculiar to them and often fatal, whether by its own action or in combination with wounds or disease.
[Dr. Scheuzer] had said that the air enclosed in the bodies of his countrymen, being in Æquilibrium with a rare and light air that surrounds them, was overloaded in lower countries with an air more dense and heavier, which compressing and obstructing the capillary vessels, makes the circulation slow and difficult, and occasions many sad symptoms. [Account of the publication of "Areographia Helvetiæ" in New Memoirs of Literature, London, March 1726]
By 1830s the word was used of any intense homesickness: that of sailors, convicts, African slaves. "The bagpipes produced the same effects sometimes in the Scotch regiments while serving abroad" [Penny Magazine," Nov. 14, 1840]. It is listed among the "endemic diseases" in the "Cyclopaedia of Practical Medicine" [London, 1833, edited by three M.D.s], which defines it as "The concourse of depressing symptoms which sometimes arise in persons who are absent from their native country, when they are seized with a longing desire of returning to their home and friends and the scenes their youth ...."
It was a military medical diagnosis principally, and was considered a serious medical problem by the North in the American Civil War:
In the first two years of the war, there were reported 2588 cases of nostalgia, and 13 deaths from this cause. These numbers scarcely express the real extent to which nostalgia influenced the sickness and mortality of the army. To the depressing influence of home-sickness must be attributed the fatal result in many cases which might otherwise have terminated favorably. ["Sanitary Memoirs of the War," U.S. Sanitary Commission, N.Y.: 1867]
Transferred sense (the main modern one) of "wistful yearning for the past" is recorded by 1920, perhaps from such use of nostalgie in French literature. The longing for a distant place also necessarily involves a separation in time.