Etymology
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weakling (n.)
1520s, coined by Tyndale from weak (adj.) + -ling as a loan-translation of Luther's Weichling "effeminate man" (from German weich "soft") in I Corinthians vi.9, where the Greek is malakoi, from malakos "soft, soft to the touch," "Like the Lat. mollis, metaph. and in a bad sense: effeminate, of a catamite, a male who submits his body to unnatural lewdness" ["Thayer's Greek-English Lexicon of the New Testament"].
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creampuff (n.)

also cream-puff, by 1859 as a kind of light confection, from cream (n.) + puff (n.). In figurative sense of "ineffectual person, weakling, sissy," it is recorded by 1935.

I remember my first campaign. My opponent called me a cream puff. That's what he said. Well, I rushed out and got the baker's union to endorse me. [Sen. Claiborne Pell, D-R.I., 1987]

As a salesman's word, "something that is a tremendous bargain," it is from 1940s.

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*mel- (1)
Proto-Indo-European root meaning "soft," with derivatives referring to soft or softened materials.

It forms all or part of: amblyopia; bland; blandish; blenny; emollient; enamel; malacia; malaxation; malt; melt; mild; Mildred; milt; moil; mollify; Mollusca; mollusk; mulch; mullein; mutton; schmaltz; smelt (v.); smelt (n.).

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit mrdh "to neglect," also "to be moist;" Greek malakos "soft," malthon "weakling;" Latin mollire "soften," mollis "soft;" Old Irish meldach "tender."
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