word-forming element meaning "long, abnormally large, on a large scale," taken into English via French and Medieval Latin from Greek makros "long, large," from PIE root *mak- "long, thin."
word-forming element meaning "seven," from Latin septem-, from septem "seven" (see seven). "The Cloister and the Hearth" (1861) has septemvious "going seven different ways" (with Latin via "way").
before vowels, cephal-, word-forming element meaning "head, skull, brain," Modern Latin combining form of Greek kephalē "head, uppermost or top part, source," from PIE *ghebh-el- (source also of Tocharian spal "head;" Old High German gebal "skull;" also, via the notion of "front," Gothic gibla, Old Norse gafl "side of a facade").
The extension of the sense to corresponding relationships of descent, "a generation younger than" (grandson, granddaughter) is from Elizabethan times. The inherited PIE root, *nepot- "grandchild" (see nephew) has shifted to "nephew; niece" in English and other languages (Spanish nieto, nieta). Old English used suna sunu ("son's son"), dohtor sunu ("son's daughter").