"disease characterized by eruptive sores," late 15c., spelling alteration of pockes (late 13c. in this sense), plural of pocke "pustule" (see pock (n.)). Especially (after c. 1500) of syphilis.
"pustule raised on the surface of the body in an eruptive disease," Middle English pok, from Old English pocc "pustule, blister, ulcer," from Proto-Germanic *puh(h)- "to swell up, blow up" (source also of Middle Dutch pocke, Dutch pok, East Frisian pok, Low German poche, dialectal German Pfoche), from PIE root *beu- "to swell, to blow" (see bull (n.2)).
French pocque is from Germanic. The plural form, Middle English pokkes "disease characterized by pustules" (late 14c.) is the source of pox.
also doggone, colloquial minced epithet, by 1849, Western American English, a "fantastic perversion of god-damned" [Weekley]. But Mencken favors the theory that it is "a blend form of dog on it; in fact it is still often used with it following. It is thus a brother to the old English phrase, 'a pox upon it,' but is considerably more decorous." Dog on it was the usual early spelling, so it was perhaps at least felt as such by those using it.
But there are many examples of similar words serving as euphemistic perversions of God: Compare dod for "God" in many oaths (late 17c. through 19c.); dodgasted (probably "God-blasted," in use late 19c., early 20c.); dod-rot (1842).
"narrow track worn or cut in the ground," as by a passing wheeled vehicle, 1570s, probably from Middle English route "way, a road, space for passage" (see route (n.)); though OED finds this "improbable." If so, it is a doublet of route.
Of the lines on the face by 1620s. The figurative meaning "narrow, monotonous routine; habitual mode of behavior or procedure" is attested by 1839 (Carlyle); earlier figurative use was as an obstacle to rapid transit (1705).
Enter an OLD LADY.
[Bosola] You come from painting now.
Old Lady. From what?
Bos. Why, from your scurvy face-physic.
To behold thee not painted, inclines somewhat near
A miracle: these in thy face here, were deep ruts,
And foul sloughs, the last progress.
There was a lady in France, that having the small-pox,
Flay'd the skin off her face, to make it more level;
And whereas before she looked like a nutmeg-grater,
After she resembled an abortive hedgehog.
[Webster, "The Duchess of Malfi"]
The verb meaning "mark with or as with ruts" is by c. 1600. Related: Rutted; rutting.