Etymology
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moccasin (n.)

1610s, foot-covering worn originally by native North American people (made of deerskin or soft leather and without a stiff sole), from an Algonquian language of Virginia, probably Powhatan makasin "shoe," from Central Atlantic Coast Algonquian *mockasin, which is similar to Southern New England Algonquian *makkusin, Munsee Delaware mahkusin, Ojibwa makizin. Related: Moccasined.

As a name for a type of venomous snake of the southern U.S. (1784), it is perhaps a different word, but none has been found to match it. Bright regards them as identical, but the sense connection is difficult to explain.

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water-moccasin (n.)
type of snake in the U.S. South, 1821, from water (n.1) + moccasin (q.v.).
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