Etymology
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issue (n.)
c. 1300, "an exit," from Old French issue "a way out, a going out, exit; final event," from fem. past participle of issir "to go out," from Latin exire "go out, go forth; become public; flow, gush, pour forth" (source also of Italian uscire, Catalan exir), from ex- "out" (see ex-) + ire "to go," from PIE root *ei- "to go."

Meaning "discharge of blood or other fluid from the body" is from 1520s; sense of "offspring, children" is from late 14c. Meaning "outcome of an action, consequence, result" is attested from late 14c., probably from this sense in French. Meaning "action of sending into publication or circulation" is from 1833.

Legal sense developed from the notion of "end or result of pleadings in a suit (by presentation of the point to be determined by trial)," hence "the controversy over facts in a trial" (early 14c., Anglo-French) and transferred sense "point of contention between two parties" (early 15c.) and the general sense "an important point to be decided" (1836). Hence also the verbal phrase take issue with (1797, earlier join issue, 1690s) "take up an affirmative or negative position in a dispute with another." To have issues "have unresolved conflicts" is by 1990.
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issue (v.)
mid-14c., of water, etc., "to flow out;" of persons, "come or go (out of a place), sally forth," from issue (n.) or else from Old French issu, past participle of issir. Transitive sense of "to send out" is from mid-15c.; specific sense of "to send out authoritatively" is from c. 1600. Meaning "supply (someone with something)" is from 1925. Related: Issued; issuing.
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issuable (adj.)
1560s, from issue (v.) + -able. Related: Issuably.
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issuance (n.)
"act of issuing," 1823, American English, from issue (v.) + -ance.
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reissue (v.)

also re-issue, 1610s, "go forth again" (intransitive), from re- "back, again" + issue (v.). Transitive sense of "send out or put forth a second time" (of banknotes, periodicals, etc.) is by 1799. Related: Reissued; reissuing. The noun, "a second or renewed issue," is attested from 1805.

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*ei- 
Proto-Indo-European root meaning "to go."

It forms all or part of: Abitur; adit; ambience; ambient; ambit; ambition; ambitious; andante; anion; cation; circuit; coitus; commence; commencement; concomitant; constable; count (n.1) title of nobility; county; dysprosium; errant; exit; initial; initiate; initiation; introit; ion; issue; itinerant; itinerary; janitor; January; Janus; Jena; Mahayana; obiter; obituary; perish; praetor; Praetorian; preterite; sedition; sudden; trance; transient; transit; transitive; viscount.

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit e'ti "goes," imas "we go," ayanam "a going, way;" Avestan ae'iti "goes," Old Persian aitiy "goes;" Greek ienai "to go;" Latin ire "to go," iter "a way;" Old Irish ethaim "I go," Irish bothar "a road" (from *bou-itro- "cows' way"), Gaulish eimu "we go;" Lithuanian eiti "to go;" Old Church Slavonic iti "go;" Bulgarian ida "I go;" Russian idti "to go;" Gothic iddja "went."
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availment (n.)
"successful issue; fact of being effective," 1690s, from avail (v.) + -ment.
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sally (v.)

of a troop or troops, "issue suddenly from a place of defense for the purpose of attack," 1540s, from sally (n.). Related: Sallied; sallying.

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ticket (v.)
1610s, "attach a ticket to, put a label on," from ticket (n.). Meaning "issue a (parking) ticket to" is from 1955. Related: Ticketed; ticketing.
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sine prole 
legalistic Latin, "without issue," from sine "without" (see sans) + prole, ablative of proles "offspring" (see prolific).
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