word-forming element typically representing cross as a noun, adverb (cross-examine), adjective (crossbar), and in many words a confluence of them. "There is no distinct line of division between cross as an adjective and cross as a prefix. As a prefix, it often represents the adv. cross, or the prep. cross, across." [Century Dictionary]
word-forming element meaning "across, beyond, through, on the other side of, to go beyond," from Latin trans (prep.) "across, over, beyond," perhaps originally present participle of a verb *trare-, meaning "to cross," from PIE *tra-, variant of root *tere- (2) "cross over, pass through, overcome." In chemical use indicating "a compound in which two characteristic groups are situated on opposite sides of an axis of a molecule" [Flood].