"gonorrhea," 1580s, of unknown origin, perhaps from Middle English clapper "rabbit-hole," from Old French clapoire (Modern French clapier), originally "rabbit burrow" (a word of uncertain origin), given a slang extension to "brothel" and also the name of a disease of some sort. In English originally also a verb, "to infect with clap." Related: Clap-doctor.
early 15c., "infect with a disease, defile," from Latin contaminatus, past participle of contaminare "to defile, to corrupt, to deteriorate by mingling," originally "to bring into contact," from contamen "contact; pollution," from assimilated form of com "with, together" (see con-) + *tag-, base of tangere "to touch" (from PIE root *tag- "to touch, handle"). Related: Contaminant (1934).
mid-14c., disesen, "to make uneasy, trouble; inflict pain," a sense now obsolete; late 14c. as "to have an illness or infection;" late 15c. in the transitive sense of "to infect with a disease, make ill;" from disease (n.). Tyndale (1526) has Thy doughter is deed, disease not the master where KJV has trouble not (Luke viii.49).