before vowels meg-, word-forming element often meaning "large, great," but in physics a precise measurement to denote the unit taken a million times (megaton, megawatt, etc.), from Greek megas "great, large, vast, big, high, tall; mighty, important" (fem. megale), from PIE root *meg- "great." Mega began to be used alone as an adjective by 1982.
High-speed computer stores 2.5 megabits [headline in "Electronics" magazine, Oct. 1, 1957]
word forming element indicating "oneself," also "automatic," from Old English use of self (pron.) in compounds, such as selfbana "suicide," selflice "self-love, pride, vanity, egotism," selfwill "free will." Middle English had self-witte "one's own knowledge and intelligence" (early 15c.).
OED counts 13 such compounds in Old English. Middle English Compendium lists four, counting the self-will group as a whole. It re-emerges as a living word-forming element mid-16c., "probably to a great extent by imitation or reminiscence of Greek compounds in (auto-)," and formed a great many words in the pamphlet disputes of the 17c.
The extension of the sense to corresponding relationships of descent, "a generation younger than" (grandson, granddaughter) is from Elizabethan times. The inherited PIE root, *nepot- "grandchild" (see nephew) has shifted to "nephew; niece" in English and other languages (Spanish nieto, nieta). Old English used suna sunu ("son's son"), dohtor sunu ("son's daughter").