before vowels meg-, word-forming element often meaning "large, great," but in physics a precise measurement to denote the unit taken a million times (megaton, megawatt, etc.), from Greek megas "great, large, vast, big, high, tall; mighty, important" (fem. megale), from PIE root *meg- "great." Mega began to be used alone as an adjective by 1982.
High-speed computer stores 2.5 megabits [headline in "Electronics" magazine, Oct. 1, 1957]
The extension of the sense to corresponding relationships of descent, "a generation younger than" (grandson, granddaughter) is from Elizabethan times. The inherited PIE root, *nepot- "grandchild" (see nephew) has shifted to "nephew; niece" in English and other languages (Spanish nieto, nieta). Old English used suna sunu ("son's son"), dohtor sunu ("son's daughter").