suffix in pet proper names (such as Johnny, Kitty), first recorded in Scottish c. 1400; according to OED it became frequent in English 15c.-16c. Extension to surnames seems to date from c. 1940. Use with common nouns seems to have begun in Scottish with laddie (1546) and become popular in English due to Burns' poems, but the same formation appears to be represented much earlier in baby and puppy.
figurative element in combinations, "at heart," also "having a heart" (of a specified kind), c. 1200, first attested in hard-hearted; see heart (n.). Related: -heartedly.
word-forming element used in forming nouns from Latin words ending in -atus, -atum (such as estate, primate, senate). Those that came to English via French often arrived with -at, but an -e was added after c. 1400 to indicate the long vowel. The suffix also can mark adjectives formed from Latin past participles in -atus, -ata (such as desolate, moderate, separate); again, they often were adopted in Middle English as -at, with an -e appended after c. 1400.
word-forming element meaning "one hundred" or "one hundredth part," used in English from c. 1800, from the French metric system, from Latin centi-, combining form of centum "one hundred" (see hundred).
before vowels chem-, word-forming element denoting "relation to chemical action or chemicals," from combining form of chemical (adj.), used to form scientific compound words from c. 1900. In 19c., chemico- was used.
suffix sporadically in vogue since c. 1840 in U.S. colloquial word formation (such as dullsville, palookaville), abstracted from the -ville in place names (Louisville, Greenville, etc.), from Old French ville "town," from Latin villa (see villa).
before vowels kary-, word-forming element used since c. 1874 in biological terms referring to cell nuclei, from Greek karyon "nut, kernel," possibly from PIE root *kar- "hard," but Beekes leans toward the notion that it is a Pre-Greek word.