"disease of alcohol addiction," by 1882, from alcohol + -ism, or else from Modern Latin alcoholismus, coined in 1852 by Swedish professor of medicine Magnus Huss to mean what we now would call "alcohol poisoning, effects of excessive ingestion of alcohol." In earlier times, alcohol addiction would have been called habitual drunkenness or some such term.
early 15c., "to misuse, misapply" (power, money, etc.), from Old French abuser "deceive, abuse, misuse" (14c.), from Vulgar Latin *abusare, from Latin abusus "an abusing; a using up," past participle of abuti "use up, consume," also "to misuse, abuse, misapply, outrage," from ab "off, away from" (see ab-) + uti "use" (see use).
Also in reference to forbidden sexual situations from early 15c., but originally meaning incest, masturbation (self-abuse), homosexuality, prostitution, etc. From 1550s specifically as "to misuse sexually, ravish," but OED 2nd ed. marks this obsolete and the modern use "subject (someone) to unwanted sexual activity" is likely a fresh coinage from late 20c. Specifically of drugs, from 1968. Meaning "attack with harsh language, revile" is from c. 1600. Related: Abused; abusing.
late 12c., drinkinge, "the action of drinking," especially drinking for pleasure, verbal noun from drink (v.). Drinking problem "alcoholism" is by 1953; earlier was drinking habit (by 1825).