It forms all or part of: accomplice; application; apply; complex; complexion; complicate; complication; complicity; deploy; display; duplex; duplicate; duplicity; employ; explicate; explicit; exploit; flax; implex; implicate; implication; implicit; imply; multiply; perplex; perplexity; plait; plash (v.2) "to interlace;" pleat; -plex; plexus; pliable; pliant; plie; plight (n.1) "condition or state;" ply (v.1) "work with, use;" ply (v.2) "to bend; ply (n.) "a layer, fold;" replica; replicate; replication; reply; simplex; splay; triplicate.
It is the hypothetical source of/evidence for its existence is provided by: Sanskrit prasna- "turban;" Greek plekein "to plait, braid, wind, twine," plektos "twisted;" Latin plicare "to lay, fold, twist," plectere (past participle plexus) "to plait, braid, intertwine;" Old Church Slavonic plesti "to braid, plait, twist," Russian plesti; Gothic flahta "braid;" Old Norse fletta, Old High German flehtan "to plait;" Old English fleax "cloth made with flax, linen."
word-forming element of Latin origin meaning 1. "lack of, not" (as in dishonest); 2. "opposite of, do the opposite of" (as in disallow); 3. "apart, away" (as in discard), from Old French des- or directly from Latin dis- "apart, asunder, in a different direction, between," figuratively "not, un-," also "exceedingly, utterly." Assimilated as dif- before -f- and to di- before most voiced consonants.
The Latin prefix is from PIE *dis- "apart, asunder" (source also of Old English te-, Old Saxon ti-, Old High German ze-, German zer-). The PIE root is a secondary form of *dwis- and thus is related to Latin bis "twice" (originally *dvis) and to duo, on notion of "two ways, in twain" (hence "apart, asunder").
In classical Latin, dis- paralleled de- and had much the same meaning, but in Late Latin dis- came to be the favored form and this passed into Old French as des-, the form used for compound words formed in Old French, where it increasingly had a privative sense ("not"). In English, many of these words eventually were altered back to dis-, while in French many have been altered back to de-. The usual confusion prevails.
As a living prefix in English, it reverses or negatives what it is affixed to. Sometimes, as in Italian, it is reduced to s- (as in spend, splay, sport, sdain for disdain, and the surnames Spencer and Spence).