Middle English mous, from Old English mus "small rodent," also "muscle of the arm" (compare muscle (n.)); from Proto-Germanic *mus (source also of Old Norse, Old Frisian, Middle Dutch, Danish, Swedish mus, Dutch muis, German Maus "mouse"), from PIE *mus-, the old Indo-European name of the mouse, retained in several language families (source also of Sanskrit mus "mouse, rat," Old Persian mush "mouse," Old Church Slavonic mysu, Latin mus, Lithuanian muse "mouse," Greek mys "mouse, muscle").
Plural form mice (Old English mys) shows effects of i-mutation. As a type of something timid or weak, from late 14c. Contrasted with man (n.) from 1620s (nor man nor mouse). Meaning "black eye" (or other discolored lump on the body) is from 1842. Computer sense of "small device moved by the hand over a flat surface to maneuver a cursor or arrow on a display screen" is from 1965, though the word was applied to other things resembling a mouse in shape since 1750, mainly in nautical use.
Parturient montes, nascetur ridiculus mus [Horace]
Middle English se, seo, from Old English sæ,"sheet of water, sea, lake, pool," from Proto-Germanic *saiwa- (source also of Old Saxon seo, Old Frisian se, Middle Dutch see, Dutch zee, German See, Swedish sjö), of unknown origin, outside connections "wholly doubtful" [Buck], and an IE etymon "has generally been doubted" [Boutkan]. The meaning "any great mass or large quantity" (of anything) is from c. 1200.
Germanic languages also use the more general Indo-European word (represented by English mere (n.1)), but have no firm distinction between "sea" and "lake," either large or small, by inland or open, salt or fresh. This may reflect the Baltic geography where the languages are thought to have originated. The two words are used more or less interchangeably in Germanic, and exist in opposite senses (such as Gothic saiws "lake, marshland," marei "sea;" but Dutch zee "sea," meer "lake"). Compare also Old Norse sær "sea," but Danish sø, usually "lake" but "sea" in phrases. German See is "sea" (fem.) or "lake" (masc.).
Boutkan writes that the sea words in Germanic likely were originally "lake," and the older word for "sea" is represented by haff. The single Old English word sæ glosses Latin mare, aequor, pontus, pelagus, and marmor. The range in the Old English word included "the expanse of salt water that covers much of the world" to individual great, distinctly limited bodies of water; it also was used of inland seas, bogs, lakes, rivers, and the Bristol Channel.
Meaning "dark area of the moon's surface" is attested from 1660s (see mare (n.2)); before the invention of telescopes they were supposed to be water. The phrase sea change "transformation," literally "a change wrought by the sea," is attested from 1610, first in Shakespeare ("The Tempest," I.ii). Sea legs, humorous colloquial term implying ability to walk on a ship's deck when she is pitching or rolling is from 1712. At sea in the figurative sense of "perplexed" is attested from 1768, from literal sense (in reference to ships) of "out of sight of land" (c. 1300).
cartoon mouse character created 1928 by U.S. animator Walt Disney (1901-1966). As an adjective meaning "small and worthless, petty, inconsequential" it was in use by 1951, perhaps from the popularity of the cheaply made Mickey Mouse wristwatch; it was used by 1935 in reference to mediocre dance-band music, based on the type of tunes played as background in cartoon films.