Etymology
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Main Street (n.)

"principal street of a (U.S.) town," 1810, from main (adj.) + street. Used allusively to indicate "mediocrity, small-town materialism" from late 19c., a sense reinforced by the publication of Sinclair Lewis's novel "Main Street" (1920).

But a village in a country which is taking pains to become altogether standardized and pure, which aspires to succeed Victorian England as the chief mediocrity of the world, is no longer merely provincial, no longer downy and restful in its leaf-shadowed ignorance. It is a force seeking to dominate the earth, to drain the hills and sea of color, to set Dante at boosting Gopher Prairie, and to dress the high gods in Klassy Kollege Klothes. Sure of itself, it bullies other civilizations, as a traveling salesman in a brown derby conquers the wisdom of China and tacks advertisements of cigarettes over arches for centuries dedicate to the sayings of Confucius. ["Main Street"]
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main (n.)

Old English mægen (Mercian megen) "power, bodily strength; force, violent effort; strength of mind or will; efficacy; supernatural power," from Proto-Germanic *maginam "power" (source also of Old High German megin "strength, power, ability"), suffixed form of PIE root *magh- "to be able, have power."

Original sense of "power" is preserved in phrase might and main. Also used in Middle English for "royal power or authority" (c. 1400), "military strength" (c. 1300), "application of force" (c. 1300). Meaning "chief or main part" (c. 1600) now is archaic or obsolete. Meaning "principal duct, pipe, or channel in a utility system" is first recorded 1727 in main drain.

Used since 1540s for "continuous stretch of land or water;" in nautical jargon used loosely for "the ocean," but in Spanish Main the word is short for mainland and refers to the coast between Panama and Orinoco (as contrasted to the islands of the West Indies).

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main (adj.)

early 13c., "notably large, bulky, or strong" (a sense now obsolete), from Old English mægen- "power, strength, force," used in compounds (such as mægensibb "great love," mægenbyrðen "heavy burden;" see main (n.)), probably also in part from or influenced by cognate Old Norse megenn (adj.) "strong, powerful, mighty."

Sense of "chief, principal, prime" is from c. 1400. That of "principal or chief in size or extent" is from 1590s. Main chance "opportunity of enriching oneself" is by 1570s, from the game of hazard. Main course in the meal sense attested from 1829. Main man "favorite male friend; hero" is by 1967, African-American vernacular.

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street (n.)

Old English stret (Mercian, Kentish), stræt (West Saxon) "street, high road," from Late Latin strata, used elliptically for via strata "paved road," from fem. past participle of Latin sternere "lay down, spread out, pave," from PIE *stre-to- "to stretch, extend," from root *stere- "to spread, extend, stretch out," from nasalized form of PIE root *stere- "to spread."

One of the few words in use in England continuously from Roman times. An early and widespread Germanic borrowing (Old Frisian strete, Old Saxon strata, Middle Dutch strate, Dutch straat, Old High German straza, German Strasse, Swedish stråt, Danish sträde "street"). The Latin is also the source of Spanish estrada, Old French estrée, Italian strada.

"The normal term in OE for a paved way or Roman road, later extended to other roads, urban streets, and in SE dialects to a street of dwellings, a straggling village or hamlet" [Cambridge Dictionary of English Place-Names]. Originally of Roman roads (Watling Street, Icknield Street). "In the Middle Ages, a road or way was merely a direction in which people rode or went, the name street being reserved for the made road" [Weekley].

Used since c. 1400 to mean "the people in the street;" modern sense of "the realm of the people as the source of political support" dates from 1931. The street for an especially important street is from 1560s (originally of London's Lombard-street). Man in the street "ordinary person, non-expert" is attested from 1831. Street people "the homeless" is from 1967; expression on the street "homeless" is from 1852. Street smarts is from 1971; street-credibility is from 1979. Street-sweeper as an occupation is from 1848.

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main line (n.)

"principal line of a railway," 1841, from main (adj.) + line (n.). Meaning "affluent area of residence" is by 1917, originally (with capitals) that west of Philadelphia, from the "main line" of the Pennsylvania Railroad which added local stops to a string of backwater towns west of the city late 19c. that helped turn them into fashionable suburbs.

The Main Line, Philadelphia's most famous suburban district, was deliberately conceived in the 1870's and 1880's by the [Pennsylvania] Railroad, which built high-toned housing developments, ran hotels, more or less forced its executives to plunk their estates out there, and created a whole series of somewhat spurious Welsh towns along the railroad tracks. ... Now everybody assumes these all date from 1682, like the Robertses; but as Chestnut Hill people like to say, "nobody but Welsh peasants lived on the Main Line till the Railroad built it up." [Nathaniel Burt, "The Perennial Philadelphians," 1963]

The original station stops were, in order out from the city, Overbrook, Merion, Narberth, Wynnewood, Ardmore, Haverford, Bryn Mawr, Paoli. The train line for commuters along it is the Paoli Local.

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Bow Street 
London street near Covent Garden, developed with homes from early 17c., the name (attested from 1680s) is from bow (n.1) in reference to its curved shape. Seat of a metropolitan police court from 1740; hence Bow Street runners, voluntery police force established here in 1750.
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street-wise (adj.)
1951, from street + wise (adj.) "smart, savvy."
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Wall Street (n.)
"U.S. financial world," 1836, from street in New York City that is home to many investment firms and stock traders, as well as NYSE. The street so called because it ran along the interior of the defensive wall of the old Dutch colonial town.
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Downing Street 
short street in London, named for British diplomat Sir George Downing (c. 1624-1684). It contains the residence of the prime minister (at Number 10), hence its metonymic use for "the British government," attested from 1781.
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Wardour-street (n.)

"affected pseudo-archaic diction of historical novels," 1888, from street in London lined with shops selling imitation-antique furniture.

This is not literary English of any date; this is Wardour-Street Early English — a perfectly modern article with a sham appearance of the real antique about it. [A. Ballantyne, "Wardour-Street English," Longman's Magazine, October, 1888]
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