late 14c., "action, performance, work," also "the performance of some science or art," from Old French operacion "operation, working, proceedings," from Latin operationem (nominative operatio) "a working, operation," noun of action from past-participle stem of operari "to work, labor" (in Late Latin "to have effect, be active, cause"), from opera "work, effort," related to opus (genitive operis) "a work" (from PIE root *op- "to work, produce in abundance").
The surgical sense of "act or series of acts performed upon a patient's body," usually with instruments, is first attested 1590s. The military sense of "act of carrying out a preconcerted series of movements" is by 1749.
word-forming element meaning "not, opposite of, without" (also im-, il-, ir- by assimilation of -n- with following consonant, a tendency which began in later Latin), from Latin in- "not," cognate with Greek an-, Old English un-, all from PIE root *ne- "not."
In Old French and Middle English often en-, but most of these forms have not survived in Modern English, and the few that do (enemy, for instance) no longer are felt as negative. The rule of thumb in English has been to use in- with obviously Latin elements, un- with native or nativized ones.
word-forming element in chemistry, usually indicating a neutral substance, antibiotic, vitamin, or hormone; a modification and specialized use of -ine (2).
the adverb in attached to a verb as a word-forming element, by 1960, abstracted from sit-in, which is attested from 1941 in reference to protests and 1937 in reference to labor union actions (which probably was influenced by sit-down strike) but was popularized in reference to civil disobedience protests aimed at segregated lunch counters.
As a word-forming element it was extended first of other types of protests, then by 1965 to any sort of communal gathering (such as love-in, attested by 1967; slim-in, for dieters, 1973). In labor actions it was perhaps less useful: "a mass of workers calling in sick to absent themselves in protest" was called both a sick-out (1970) and a sick-in (1974).
a Middle English merger of Old English in (prep.) "in, into, upon, on, at, among; about, during;" and Old English inne (adv.) "within, inside," from Proto-Germanic *in (source also of Old Frisian, Dutch, German, Gothic in, Old Norse i), from PIE root *en "in." The simpler form took on both senses in Middle English.
Sense distinction between in and on is from later Middle English, and nuances in use of in and at still distinguish British and American English (in school/at school). Sometimes in Middle English shortened to i.
The noun sense of "influence, access (to power or authorities)," as in have an in with, is first recorded 1929 in American English. to be in for it "certain to meet with something unpleasant" is from 1690s. To be in with "on friendly terms with" is from 1670s. Ins and outs "intricacies, complications of an action or course" is from 1660s. In-and-out (n.) "copulation" is attested from 1610s.
element meaning "into, in, on, upon" (also im-, il-, ir- by assimilation of -n- with following consonant), from Latin in- "in," from PIE root *en "in."
In Old French (and hence in Middle English) this often became en-, which in English had a strong tendency to revert to Latin in-, but not always, which accounts for pairs such as enquire/inquire. There was a native form, which in West Saxon usually appeared as on- (as in Old English onliehtan "to enlighten"), and some of those verbs survived into Middle English (such as inwrite "to inscribe"), but all now seem to be extinct.
Not related to in- (1) "not," which also was a common prefix in Latin, causing confusion: to the Romans impressus could mean "pressed" or "unpressed;" inaudire meant "to hear," but inauditus meant "unheard of;" in Late Latin investigabilis could mean "that may be searched into" or "that cannot be searched into." Latin invocatus was "uncalled, uninvited," but invocare was "to call, appeal to."
The trouble has continued in English; the hesitation over what is meant by inflammable being a commonly cited example. Implume (1610s) meant "to feather," but implumed (c. 1600) meant "unfeathered." Impliable can mean "capable of being implied" (1865) or "inflexible" (1734). Impartible in 17c. could mean "incapable of being divided" or "capable of being imparted." Impassionate can be "free from passion" or it can mean "strongly stirred by passion." Inanimate (adj.) is "lifeless," but Donne uses inanimate (v.) to mean "infuse with life or vigor." Irruption is "a breaking in," but irruptible is "unbreakable."
In addition to improve "use to one's profit," Middle English also had a verb improve meaning "to disprove" (15c.). To inculpate is "to accuse," but inculpable means "not culpable, free from blame." Infestive has meant "troublesome, annoying" (1560s, from infest) and "not festive" (1620s). In Middle English inflexible could mean "incapable of being bent" or "capable of being swayed or moved." In 17c., informed could mean "current in information," formed, animated," or "unformed, formless" ("This was an awkward use" [OED]). Inhabited has meant "dwelt in" (1560s) and "uninhabited" (1610s); inhabitable likewise has been used on opposite senses, a confusion that goes back to Late Latin.
1894, "anyone of a relationship not natural," abstracted from father-in-law, etc.
The position of the 'in-laws' (a happy phrase which is attributed ... to her Majesty, than whom no one can be better acquainted with the article) is often not very apt to promote happiness. [Blackwood's Magazine, 1894]
The earliest recorded use of the formation is in brother-in-law (13c.); the law is Canon Law, which defines degrees of relationship within which marriage is prohibited. Thus the word originally had a more narrow application; its general extension to more distant relatives of one's spouse is, according to OED "recent colloquial or journalistic phraseology." Middle English inlaue (13c.) meant "one within or restored to the protection and benefit of the law" (opposite of an outlaw), from a verb inlauen, from Old English inlagian "reverse sentence of outlawry."
Latin, "as a whole, wholly, completely, utterly, entirely," from toto, ablative of totus "whole, entire" (see total (adj.)); "always or nearly always with verbs of negative sense" [Fowler].