Old English giefan (West Saxon) "to give, bestow, deliver to another; allot, grant; commit, devote, entrust," class V strong verb (past tense geaf, past participle giefen), from Proto-Germanic *geban (source also of Old Frisian jeva, Middle Dutch gheven, Dutch geven, Old High German geban, German geben, Gothic giban), from PIE root *ghabh- "to give or receive." It became yiven in Middle English, but changed to guttural "g" by influence of Old Norse gefa "to give," Old Danish givæ.
Meaning "to yield to pressure" is from 1570s. Give in "yield" is from 1610s; give out is mid-14c. as "publish, announce;" meaning "run out, break down" is from 1520s. Give up "surrender, resign, quit" is mid-12c. To give (someone) a cold seems to reflect the old belief that one could be cured of disease by deliberately infecting others. What gives? "what is happening?" is attested from 1940. To not give a (some thing regarded as trivial and valueless) is from c. 1300 (early examples were a straw, a grass, a mite).
Old English up, uppe, from Proto-Germanic *upp- "up" (source also of Old Frisian, Old Saxon up "up, upward," Old Norse upp; Danish, Dutch op; Old High German uf, German auf "up"; Gothic iup "up, upward," uf "on, upon, under;" Old High German oba, German ob "over, above, on, upon"), from PIE root *upo "under," also "up from under," hence also "over."
As a preposition, "to a higher place" from c. 1500; also "along, through" (1510s), "toward" (1590s). Often used elliptically for go up, come up, rise up, etc. Up the river "in jail" first recorded 1891, originally in reference to Sing Sing, which is up the Hudson from New York City. To drive someone up the wall (1951) is from the notion of the behavior of lunatics or caged animals. Insulting retort up yours (scil. ass) is attested by late 19c.
1550s, "to drive and catch (swans)," from up (adv.). Intransitive meaning "get up, rise to one's feet" (as in up and leave) is recorded from 1640s. Sense of "to move upward" is recorded from 1737. Meaning "increase" (as in up the price of oil) is attested from 1915. Compare Old English verb uppian "to rise up, swell." Related: Upped; upping. Upping block, used for mounting or dismounting horses, carriages, etc., is attested from 1796 (earlier was horsing-block, 1660s).