late 15c. (Caxton), "destroy or derange the order of, throw into confusion," from dis- "not" (see dis-) + order (v.). Replaced earlier disordeine (mid-14c.), from Old French desordainer, from Medieval Latin disordinare "throw into disorder," from Latin dis- + ordinare "to order, regulate," from ordo (genitive ordinis) "row, rank, series, arrangement" (see order (n.)). Related: Disordered; disordering.

1520s, "lack of regular arrangement;" 1530s, "tumult, disturbance of the peace;" from disorder (v.). Meaning "an ailment, a disturbance of the body or mind" is by 1704.

1580s, "opposed to moral order, disposed to violate the restraints of public morality;" also "opposed to legal authority, disposed to violate law;" see disorder (n.) + -ly (1). The meaning "untidy, being out of proper order" is attested from 1630s; the older senses are those in disorderly house, disorderly conduct, etc.

"to make untidy, put in a state of disorder," 1837, American English, probably a variant of mess in its sense of "to disorder." It was attested earlier (1830) as a noun meaning "disturbance, state of confusion." Related: Mussed; mussing.

late 13c., "mental distress, emotional disorder of the mind, grief," from Old French destorbance (12c., Old North French distorbance), from destourber, from Latin disturbare "throw into disorder," from dis- "completely" (see dis-) + turbare "to disorder, disturb," from turba "turmoil" (see turbid).

Meaning "public disturbance, political agitation" is from c. 1300; that of "violent interruption of peace or unity" is late 14c.; it is the sense in disturbance of the (king's) peace," early 15c.

"periodontal disorder," 1842; see periodontal + -itis "inflammation;" though in this case inflammation often is not a feature of the disease.

"state of being disordered or ruffled," hence "agitation, perturbation," 1813 (carfuffle), first attested in Scottish writers, from a verb meaning "to disorder, dishevel" (1580s), of obscure origin, probably from a dialect word based on Scottish verb fuffle "to throw into disorder" (1530s). The first element is perhaps as in kersplash, etc. (see ker-); OED points rather to a Gaelic car "twist, bend, turn about".