c. 1300, affliccioun, "misery, sorrow, pain, distress" (originally especially "self-inflicted pain, self-mortification, religious asceticism"), from Old French afliction "act of humility, humiliation, mortification, punishment" (11c.) and directly from Latin afflictionem (nominative afflictio), noun of action from past-participle stem of affligere "to dash down, overthrow," from ad "to" (see ad-) + fligere (past participle flictus) "to strike" (see afflict). Meaning "a cause of constant pain or sorrow" is from 1590s.
"I know, O Lord [says the Psalmist] that thy judgments are right, and that thou in faithfulness hast afflicted me;" the furnace of affliction being meant but to refine us from our earthly drossiness, and soften us for the impression of Gods own stamp and image. [Robert Boyle, "Seraphic Love," 1663]
"a state of affliction or oppression, suffering, distress," c. 1200, from Old French tribulacion (12c.), from Church Latin tribulationem (nominative tribulatio) "distress, trouble, affliction," noun of action from past-participle stem of tribulare "to oppress, afflict," a figurative use by Christian writers of Latin tribulare "to press," also possibly "to thresh out grain," from tribulum "threshing sledge," from stem of terere "to rub" (from PIE root *tere- (1) "to rub, turn") + -bulum, suffix forming names of tools.
late 14c., "state of grievous affliction, condition of external unhappiness," from Old French misere "miserable situation, misfortune, distress" (12c.), from Latin miseria "wretchedness," from miser "wretched, pitiable" (see miser). Meaning "condition of one in great sorrow or mental distress" is from 1530s.
early 13c., "hardship, suffering, pain, bodily affliction," from Old French grief "wrong, grievance, injustice, misfortune, calamity" (13c.), from grever "afflict, burden, oppress," from Latin gravare "make heavy; cause grief," from gravis "weighty" (from PIE root *gwere- (1) "heavy"). Meaning "mental pain, sorrow" is from c. 1300. Good grief as an exclamation of surprise, dismay, etc., is from 1912.