It forms all or part of: acacia; acanthus; accipiter; acer; acerbic; acerbity; acervate; acervulus; acescent; acetic; acid; acicular; acme; acne; acrid; acridity; acrimony; acro-; acrobat; acromegaly; acronym; acrophobia; acropolis; acrostic; acrylic; acuity; aculeate; acumen; acupressure; acupuncture; acute; aglet; ague; Akron; anoxic; awn; coelacanth; dioxin; deoxy-; eager; ear (n.2) "grain part of corn;" edge (n.); egg (v.) "to goad on, incite;" eglantine; epoxy; ester; exacerbation; hammer; hypoxia; mediocre; oxalic; oxide; oxy-; oxygen; oxymoron; paragon; pyracanth; paroxysm; selvage; vinegar.
It is the hypothetical source of/evidence for its existence is provided by: Greek akros "at the end, at the top, outermost; consummate, excellent," akis "sharp point," akros "at the farthest point, highest, outermost," akantha "thorn," akme "summit, edge," oxys "sharp, bitter;" Sanskrit acri- "corner, edge," acani- "point of an arrow," asrih "edge;" Oscan akrid (ablative singular) "sharply;" Latin acer (fem. acris) "sharp to the senses, pungent, bitter, eager, fierce," acutus "sharp, pointed," acuere "to sharpen," acerbus "harsh, bitter," acere "be sharp, be bitter," acus "a needle, pin," ocris "jagged mountain;" Lithuanian ašmuo "sharpness," akstis "sharp stick;" Old Lithuanian aštras, Lithuanian aštrus "sharp;" Old Church Slavonic ostru, Russian óstryj "sharp;" Old Irish er "high;" Welsh ochr "edge, corner, border;" Old Norse eggja "goad;" Old English ecg "sword;" German Eck "corner."
"becoming sour," 1670s, from French acescent, from Latin acescentem (nominative acescens), present participle of acescere "become sour," from acer "sharp" (from PIE root *ak- "be sharp, rise (out) to a point, pierce").
"brain-sand" (anatomical), 1806, medical Latin, literally "little heap," diminutive of Latin acervus "heap," which is akin to acer "sharp" (from PIE root *ak- "be sharp, rise (out) to a point, pierce").
"to heap up," 1610s, from Latin acervatus, past participle of acervare "to heap up," from acervus "heap," which is akin to acer "sharp," from PIE root *ak- "be sharp, rise (out) to a point, pierce." Related: Acervated; acervating; acerval; acervative; acervuline "occurring in clusters; clustered" (by 1859).
1540s, "quality of being sharp or pungent in taste," from French acrimonie or directly from Latin acrimonia "sharpness, pungency of taste," figuratively "acrimony, severity, energy," abstract noun from acer "sharp" (fem. acris), from PIE root *ak- "be sharp, rise (out) to a point, pierce") + -monia suffix of action, state, condition. Figurative extension to personal sharpness or bitterness is by 1610s.
1570s, from French acerbité, from Latin acerbitatem (nominative acerbitas) "harshness, sharpness, bitterness, sourness," literal and figurative (as in virus acerbitatis "the poison of malice"), from acerbus "bitter to taste, sharp, sour, tart," from Proto-Italic *akro-po- "sharp" (from PIE root *ak- "be sharp, rise (out) to a point, pierce"). Earliest use in English is figurative, of "sharp and bitter" persons. Of tastes, from 1610s. Latin acerbus is related to acer "sharp" as superbus "haughty" to super "above."
"act of exacerbating; state of being exacerbated; increase of violence or virulence, aggravation," c. 1400, exacerbacioun, from Late Latin exacerbationem (nominative exacerbatio), noun of action from past-participle stem of Latin exacerbare "exasperate, irritate, provoke," from ex, here probably "thoroughly" (see ex-), + acerbus "harsh, bitter," from acer "sharp, keen," from PIE root *ak- "be sharp, rise (out) to a point, pierce." Oldest use in English is Biblical, in reference to the Provocation in the Wilderness.