mid-14c., "state or fact of knowing; what is known, knowledge (of something) acquired by study; information;" also "assurance of knowledge, certitude, certainty," from Old French science "knowledge, learning, application; corpus of human knowledge" (12c.), from Latin scientia "knowledge, a knowing; expertness," from sciens (genitive scientis) "intelligent, skilled," present participle of scire "to know."
The original notion in the Latin verb probably is "to separate one thing from another, to distinguish," or else "to incise." This is related to scindere "to cut, divide" (from PIE root *skei- "to cut, split;" source also of Greek skhizein "to split, rend, cleave," Gothic skaidan, Old English sceadan "to divide, separate").
OED writes that the oldest English sense of the word now is restricted to theology and philosophy. From late 14c. in English as "book-learning," also "a particular branch of knowledge or of learning, systematized knowledge regarding a particular group of objects;" also "skillfulness, cleverness; craftiness." From c. 1400 as "experiential knowledge;" also "a skill resulting from training, handicraft; a trade."
From late 14c. in the more specific sense of "collective human knowledge," especially that gained by systematic observation, experiment, and reasoning. The modern (restricted) sense of "body of regular or methodical observations or propositions concerning a particular subject or speculation" is attested by 1725; in 17c.-18c. this commonly was philosophy.
The sense of "non-arts studies" is attested from 1670s. The distinction is commonly understood as between theoretical truth (Greek epistemē) and methods for effecting practical results (tekhnē), but science sometimes is used for practical applications and art for applications of skill.
The predominant modern use, "natural and physical science," generally restricted to study of the phenomena of the material universe and its laws, is by mid-19c.
To blind (someone) with science "confuse by the use of big words or complex explanations" is attested from 1937, originally noted as a phrase from Australia and New Zealand.
The men who founded modern science had two merits which are not necessarily found together: Immense patience in observation, and great boldness in framing hypotheses. The second of these merits had belonged to the earliest Greek philosophers; the first existed, to a considerable degree, in the later astronomers of antiquity. But no one among the ancients, except perhaps Aristarchus, possessed both merits, and no one in the Middle Ages possessed either. [Bertrand Russell, "A History of Western Philosophy," 1945]
Science, since people must do it, is a socially embedded activity. It progresses by hunch, vision, and intuition. Much of its change through time does not record a closer approach to absolute truth, but the alteration of cultural contexts that influence it so strongly. Facts are not pure and unsullied bits of information; culture also influences what we see and how we see it. Theories, moreover, are not inexorable inductions from facts. The most creative theories are often imaginative visions imposed upon facts; the source of imagination is also strongly cultural. [Stephen Jay Gould, introduction to "The Mismeasure of Man," 1981]
late Old English mægester "a man having control or authority over a place; a teacher or tutor of children," from Latin magister (n.) "chief, head, director, teacher" (source of Old French maistre, French maître, Spanish and Italian maestro, Portuguese mestre, Dutch meester, German Meister), contrastive adjective ("he who is greater") from magis (adv.) "more," from PIE *mag-yos-, comparative of root *meg- "great." The form was influenced in Middle English by Old French cognate maistre.
From late 12c. as "man eminently or perfectly skilled in something," also "one who is chief teacher of another (in religion, philosophy, etc.), religious instructor, spiritual guide." Sense of "master workman or craftsman, workman who is qualified to teach apprentices and carry on a trade on his own account" is from c. 1300. The meaning "one charged with the care, direction, oversight, and control of some office, business, etc." is from mid-13c.; specifically as "official custodian of certain animals kept for sport" early 15c. (maister of þe herte houndes; the phrase master of the hounds is attested by 1708). As a title of the head or presiding officer of an institution, late 14c.; as "captain of a merchant vessel" early 14c.
In the broadest sense, "one who has power to control, use, or dispose (of something or some quality) at will," from mid-14c. Also from mid-14c. as "one who employs another or others in his service" (in which sense the correlative word was servant, man, or apprentice); also "owner of a living creature" (a dog, a horse, also, in ancient contexts a slave); paired with slave in the legal language of the American colonies by 1705 in Virginia.
In academic sense "one who has received a specific degree" (translating Medieval Latin magister) it is attested from mid-13c., originally "one who has received a degree conveying authority to teach in the universities;" master's degree, originally a degree giving one authority to teach in a university, is from late 14c.
Also used in Middle English of dominant women. From 1530s as "male head of a household." As a title or term of respect or rank, mid-14c. As a title prefixed to the name of a young gentleman or boy of the better class not old enough to be called Mr., short for young master (late 16c.). Sense of "chess player of the highest class at national or international level" is by 1894. Meaning "original of a recording" is by 1904.
As an adjective from late 12c. Master-key, one that will open ("master") a number of locks so differently constructed that the key proper to each will open none of the others" is from 1570s. Master race "race of people considered to be pre-eminent in greatness or power" (typical in reference to Nazi theories of the Aryan race, perhaps based on German Herrenvolk) is by 1935. From 1530 as "artist of distinguished skill;" old masters is attested by 1733.
Master bedroom, "bedroom designed for the use of the owner of the property," as opposed to bedrooms for children or guests, is by 1919 in U.S. home-builders publications (e.g. Building Age, April 1919). It seems to be based on the English master's bedroom (by 1903) "bedroom of a headmaster or other master at an English boarding school or other similar institution."
The top floor was treated much the same as the two lower ones. Here the closet was made just a bit larger so as to allow for a bathtub, thus pushing the partition forward, making the front room less deep than the rooms below, yet paradoxically larger, because it takes in the whole front of the house. This is what is known in English advertisements as the "Master's bedroom." [The House Beautiful, June 1921]