"having difficulty evacuating the bowels while they are filled or crammed with fecal matter," 1530s, past-participle adjective from constipate (v.).
"matter used in vaccination," 1846, from French vaccin, noun use of adjective, from Latin vaccina, fem. of vaccinus "pertaining to a cow" (see vaccination). Related: Vaccinal; vaccinic.
mid-14c., "what in the world," emphatic of what, with ever. From late 14c. as "anything at all; all of; no matter what or who." From late 14c. as an adjective, "any sort of, any, every; no matter what, regardless of what." From 1870 as "whatever may be the cause, at any event," which could be the source of the modern teen slang dismissive use, which Partridge dates to 1989.
"corruption, rottenness, putrid matter," 1630s, from Medieval Latin putriditas, from Latin putridus (see putrid). In this sense Middle English had putrede (c. 1400).