"having difficulty evacuating the bowels while they are filled or crammed with fecal matter," 1530s, past-participle adjective from constipate (v.).
"those who are sick, persons suffering from illness," Old English seoce, from the source of sick (adj.). Colloquial sense of "vomited matter" is by 1959.
mid-14c., "what in the world," emphatic of what, with ever. From late 14c. as "anything at all; all of; no matter what or who." From late 14c. as an adjective, "any sort of, any, every; no matter what, regardless of what." From 1870 as "whatever may be the cause, at any event," which could be the source of the modern teen slang dismissive use, which Partridge dates to 1989.