abstract suffix of state, from Old English dom "statute, judgment" (see doom (n.)). Originally an independent word, but already active as a suffix in Old English (as in freodom, wisdom). Cognate with German -tum (Old High German tuom). "Jurisdiction," hence "province, state, condition, quality."
also auto-immune, "arising from an abnormal immune response to a normal body part," 1952, from auto- + immune. Related: Autoimmunity, attested by 1903 as "immunity, natural or acquired, effected by the unaided powers of the organism, independent of external agencies." Modern sense of "immune responses of an organism against its own healthy cells and tissues" is from 1950s.
"one of the external openings of the nose, a nasal orifice," late 14c., nostrille, from Old English nosþyrl, nosðirl, literally "the hole of the nose," from nosu "nose" (from PIE root *nas- "nose") + þyrel "hole" (from PIE root *tere- (2) "cross over, pass through, overcome"). For metathesis of -r- and vowel, see wright. After the second element became obsolete as an independent, its form was corrupted in the compound.
"native or inhabitant of the Dominican Republic," 1853, from the name of the republic, which became independent from Haiti in 1844; formerly it was Santo Domingo, the name of the capital and of the European colony established there in 1494, which was named for Santo Domingo de Guzmán, founder of the Order of the Dominicans, who established a presence there (see Dominican (1)).
1640s, as a theological term (in reference to "covenants" between God and man), from French fédéral, an adjective formed from Latin foedus (genitive foederis) "covenant, league, treaty, alliance" (from PIE *bhoid-es-, suffixed form of root *bheidh- "to trust, confide, persuade").
Secular meaning "pertaining to a covenant or treaty" (1650s) led to political sense of "formed by agreement among independent states" (1707), from use of the word in federal union "union based on a treaty" (popularized during formation of U.S.A. 1776-1787) and like phrases. Also from this period in U.S. history comes the sense "favoring the central government" (1788) and the especial use of the word (as opposed to confederate) to mean a state in which the federal authority is independent of the component parts within its legitimate sphere of action. Used from 1861 in reference to the Northern forces in the American Civil War.