Old English lætan (Northumbrian leta) "to allow; to leave behind, depart from; leave undone; bequeath," also "to rent, put to rent or hire" (class VII strong verb; past tense let, leort, past participle gelæten), from Proto-Germanic *letan (source also of Old Saxon latan, Old Frisian leta, Dutch laten, Old High German lazan, German lassen, Gothic letan "to leave, let"), from PIE *led-, extended form of root *‌‌lē- "to let go, slacken." If that derivation is correct, the etymological sense might be "let go through weariness, neglect."

The idea of slackening lies at the root of both applications of the term. When we speak of letting one go, letting him do something, we conceive him as previously restrained by a band, the loosening or slackening of which will permit the execution of the act in question. ... At other times the slackness is attributed to the agent himself, when let acquires the sense of being slack in action, delaying or omitting to do. [Hensleigh Wedgwood, "A Dictionary of English Etymology," 1859] 

He points to similar developments in French laisser "to let" from Latin laxare "to slacken," German lassen "to permit, to let," from dialectal lass "loose."

"The shortening of the root vowel ... has not been satisfactorily explained" [OED]. Of blood, from late Old English. Other Old and Middle English senses include "regard as, consider; behave toward; allow to escape; pretend;" to let (someone) know and to let fly (arrows, etc.) preserve the otherwise obsolete sense of "to cause to."

To let (someone) off "allow to go unpunished, excuse from service" is from 1814. To let on is from 1725 as "allow (something) to be known, betray one's knowledge of," 1822 as "pretend" (OED finds a similar use in the phrase never let it on him in a letter from 1637). To let out is late 12c. as "allow to depart" (transitive); intransitive use "be concluded," of schools, meetings, etc., is from 1888, considered by Century Dictionary (1895) to be "Rural, U.S." Of garments, etc., late 14c.

Let alone "abstain from interfering with" is in Old English; the phrase in the sense "not to mention, to say nothing of" is from 1812. To let (something) be "leave it alone" is from c. 1300; let it be "let it pass, leave it alone" is from early 14c. To let go is from c. 1300 as "allow to escape," 1520s as "cease to restrain," 1530s as "dismiss from one's thoughts." Let it go "let it pass, no matter" is as old as Chaucer's Wife of Bath: "But age allas Hath me biraft my beautee Lat it go, far wel, the deuel go ther with!" [c. 1395]. Let me see "show me" is from c. 1300.

Middle English sēn, from Old English seon (Anglian sean) "be or become aware of by means of the eye; look, behold;" also "perceive mentally, understand; experience; visit (a place); inspect" (contracted class V strong verb; past tense seah, past participle sewen), from Proto-Germanic *sehwanan (source also of Old Saxon, Old High German sehan, Middle High German, German sehen, Old Frisian sia, Middle Dutch sien, Old Norse sja, Gothic saihwan).

This is reconstructed to be from PIE root *sekw- (2) "to see." That PIE root often was said to be probably identical with *sekw- (1) "to follow," which produced words for "say" in Greek and Latin, and also words for "follow" (such as Latin sequor), but "opinions differ in regard to the semantic starting-point and sequences" [Buck]. Thus see might mean, etymologically, "follow with the eyes" (and in some languages extending to "speak, say, tell"). But OED finds this "involves a hypothetical sense-development which it is not easy to accept with confidence," and Boutkan also doubts the connection and gives the word "No certain PIE etymology." 

It is attested by late Old English as "be able to see with the eyes, have the faculty of sight, not be blind."

As the sense of sight affords far more complete and definite information respecting external objects than any other of the senses, mental perceptions are in many (perh. in all) languages referred to in visual terms, and often with little or no consciousness of metaphor. [OED]

English see has been used in many of these senses since early Middle English: "foresee; behold in the imagination or in a dream," also "to recognize the force of (a demonstration)," all c. 1200.

It is attested by c. 1300 as "ensure, make sure" (something is so, someone does something). To see to is by late 14c. as "be attentive to, take special care about" (also "to look at"); hence "attend to, arrange for, bring about as a result." See to it "take special care; see that it be done" is from late 15c.

The sense of "escort" (as in see you home) is attested c. 1600 in Shakespeare. The meaning "to receive as a visitor" is attested from c. 1500. The wagering sense of "equal a bet, accept by staking a similar sum" is by 1590s. Used in phrases expressing comparative and superlative (best I've ever seen) from early 14c.

Imperative use of see! "look! behold!" is by early 14c. Emphatic expression see here is attested from early 15c.; probably the notion is "see, here is ...;" but the modern use of it as "a brusque form of address used to preface an order," etc. [OED] is by 1897 in schoolboy talk. The qualifying expression as far as I can see is attested from 1560s.

Let me see as a statement expressing consideration when the speaker is trying to recall something is recorded from 1510s. See you as a casual farewell is attested by 1891 (see you soon; probably short for hope to see you soon). To see something in (someone, etc.) "perceive good or attractive qualities in" is by 1832.

Old English, "move swiftly by using the legs, go on legs more rapidly than walking," also "make haste, hurry; be active, pursue or follow a course," and, of inanimate things, "to move over a course."

The modern verb is a merger of two related Old English words, in both of which the initial two letters sometimes switched places. The first is intransitive rinnan, irnan "to run, flow, run together" (past tense ran, past participle runnen), which is cognate with Middle Dutch runnen, Old Saxon, Old High German, Gothic rinnan, German rinnen "to flow, run."

The second is Old English transitive weak verb ærnan, earnan "ride, run to, reach, gain by running" (probably a metathesis of *rennan), from Proto-Germanic *rannjanan, causative of the root *ren- "to run." This is cognate with Old Saxon renian, Old High German rennen, German rennen, Gothic rannjan.

Watkins says both are from PIE *ri-ne-a-, nasalized form of root *rei- "to run, flow," but Boutkan's sources find this derivation doubtful based on the poor attestation of supposed related forms, and he lists it as of "No certain IE etymology."

Of streams, etc., "to flow," from late Old English. From c. 1200 as "take flight, retreat hurriedly or secretly." Phrase run for it "take flight" is attested from 1640s.

Also from c. 1200 as "compete in a race." Extended to "strive for any ends," especially "enter a contest for office or honors, stand as a candidate in an election" (1826, American English).

Of any sort of hurried travel, c. 1300. From early 13c. as "have a certain direction or course." By c. 1300 as "keep going, extend through a period of time, remain in existence." Specifically of theater plays by 1808. Of conveyances, stage lines, etc., "perform a regular passage from place to place" by 1817.

Of machinery or mechanical devices, "go through normal or allotted movements or operation," 1560s. Of colors, "to spread in a fabric when exposed to moisture," 1771. Of movie film, "pass between spools," hence "be shown," by 1931.

The meaning "carry on" (a business, etc.) is by 1861, American English; hence extended senses of "look after, manage." As "publish or print in a newspaper or magazine," by 1884. 

Many senses are via the notion of "pass into or out of a certain state." To run dry "cease to yield water or milk" (1630s). In commerce, "be of a specified price, size, etc.," by 1762. To run low "be nearly exhausted" is by 1712; to run short "exhaust one's supply" is from 1752; to run out of in the same sense is from 1713. To run on "keep on, continue without pause or change" is from 1590s.

The transitive sense of "cause to run" was in Old English. By late 15c. as "to pierce, stab," hence 1520s as "thrust through or into something." The meaning "enter (a horse) in a race" is from 1750. The sense of "cause a mechanical device to keep moving or working" is by 1817.

Many figurative uses are from horseracing or hunting (such as to run (something) into the ground "carry to excess, exhaust by constant pursuit," 1836, American English).

To run across "meet by chance, fall in with" is attested from 1855, American English. To run into in this sense is by 1902. To run around with "consort with" is from 1887.

In reference to fevers by 1918. To run a (red) traffic signal is by 1933. Of tests, experiments, etc., by 1947. Of computers by 1952. Time has been running out since c. 1300. To run in the family is by 1771. The figurative expression run interference (1929) is from U.S. football. To run late is from 1954.