"evil-doing, malevolent treatment," early 13c., verbal noun from ill (v.).
"sick, ill, suffering," 1590s, present-participle adjective from ail (v.).
1620s, "feeling of petulant displeasure, fit of ill humor," colloquial, perhaps imitative of an exclamation of disgust (compare German muffen "to sulk").
"in spite of, notwithstanding," mid-14c., from Old French maugre, maulgrec "in spite of" (Modern French malgré), elliptical use of the noun maugre "ill-will, spite," from Latin malus "bad, ill, unpleasant" (see mal-) + gratum "a pleasant thing," noun use of neuter of gratus "pleasing, welcome, agreeable" (from suffixed form of PIE root *gwere- (2) "to favor"). The noun maugre "ill-will" also was in Middle English (c. 1300). For sense, compare in spite of.