In reference to dark eyes, often as a mark of beauty, from 1660s. Black-eyed is from 1590s of women, of peas from 1728. The black-eyed Susan as a flower (various species) so called from 1881, for its appearance. It also was the title of a poem by John Gay (1685-1732), which led to a popular mid-19c. British stage play of the same name.
All in the Downs the fleet was moored,
The streamers waving in the wind,
When black-eyed Susan came aboard,
"Oh! where shall I my true love find?
Tell me, ye jovial sailors, tell me true,
If my sweet William sails among the crew?"
"airplane flight which deprives travelers of sleep," 1968, from the red eyes of sleeplessness; earlier it was a noun meaning "raw and inferior whiskey" (1819, American English); it also has been used of various fish.