c. 1600, "to mix (a drink, etc.) with drugs, make narcotic or poisonous," from drug (n.). Meaning "dose (a person or animal) to excess with drugs or medications" is from 1730. Related: drugged; drugging.
Old English wired "made of wire," past-participle adjective from wire (v.). From early 15c. as "stiffened by wires." Meaning "nervous, jittery" is by 1970s; earlier (1959, perhaps early 1950s) "using narcotic drugs, addicted to drugs."
"one who opposes, an adversary, an antagonist," 1580s, from noun use of Latin opponentem (nominative opponens), present participle of opponere "oppose, object to," literally "set against, set opposite," from assimilated form of ob "in front of, in the way of" (see ob-) + ponere "to put, set, place" (see position (n.)). Originally "one who maintains a contrary argument in a disputation;" the general sense is by 1610s.
"position from which it is difficult to move," 1809, American English, from fix (v.). Meaning "dose of narcotic" is from 1934, shortened from fix-up (1867, originally in reference to liquor). Meaning "reliable indication of the position of a ship, plane, etc." (by reference to fixed positions) is from 1902.
"dried leaves of Cannabis Indica," 1590s, from Hindi bhang "narcotic from hemp," from Sanskrit bhangah "hemp," which is perhaps cognate with Russian penika "hemp." The word first appears in Western Europe in Portuguese (1560s). It also was borrowed into Persian (bang) and Arabic (banj).
type of bulbous flowering plant, 1540s, from Latin narcissus, from Greek narkissos, a plant name, not the modern narcissus, possibly a type of iris or lily, associated with Greek narkē "numbness" (see narcotic (n.)) because of the sedative effect of the alkaloids in the plant, but Beekes considers this folk-etymology and writes that "The suffix clearly points to a Pre-Greek word."
name of an intoxicant used in ancient Vedic ritual, prepared from the juice of some East Indian plant, 1785, from Sanskrit soma, from PIE *seu- "juice," from root *seue- (2) "to take liquid" (see sup (v.2)). In "Brave New World" (1932), the name of a state-dispensed narcotic producing euphoria and hallucination.
"medicine containing opium," early 15c., from Medieval Latin opiatus, from Latin opium (see opium). Figurative sense of "anything that dulls the feelings and induces rest or inaction" is from 1640s. From 1540s in English as an adjective, "made with or containing opium," hence "inducing sleep, narcotic."