1660s, "arouse by knocking at the door," from knock (v.) + up (adv.). However it is little used in this sense in American English, where the phrase means "get a woman pregnant" (1813), possibly ultimately from knock in a sense "to copulate with" (1590s; compare slang knocking-shop "brothel," 1860).
Knocked up in the United States, amongst females, the phrase is equivalent to being enciente, so that Englishmen often unconsciously commit themselves when amongst our Yankee cousins. [John Camden Hotten, "The Slang Dictionary," London, 1860]
proverbial for "something extremely rare or non-existent" (late 14c.) is from Juvenal ["Sat." vi. 164], but the real thing turned up in Australia (Chenopsis atratus).
"Do you say no worthy wife is to be found among all these crowds?" Well, let her be handsome, charming, rich and fertile; let her have ancient ancestors ranged about her halls; let her be more chaste than all the dishevelled Sabine maidens who stopped the war—a prodigy as rare upon the earth as a black swan! yet who could endure a wife that possessed all perfections? I would rather have a Venusian wench for my wife than you, O Cornelia, mother of the Gracchi, if, with all your virtues, you bring me a haughty brow, and reckon up Triumphs as part of your marriage portion. [Juvenal]
Blue dahlia also was used 19c. for "something rare and unheard of."
slang phrase meaning, more or less, "I don't care, I don't worry," 1913, of unknown origin, but perhaps derived from Yiddish nisht gefidlt. Said to have been popularized by comedienne Fanny Brice (1891-1951), but earliest references do not mention her.
Chicken pox doesn't poison the wellsprings of one's existence like 'Ish kabibble,' and 'I should worry.!' Do you think it's any fun to bring up children to speak decent English, and then have their conversation strewed with phrases like that and with ain'ts? Do you think I like to hear Robert talking about his little friends as 'de guys' and 'de ginks?' [Mary Heaton Vorse, "Their Little Friends," in Woman's Home Companion, February 1916]