word-forming element meaning "make, make into," from French -fier, from Latin -ficare, combining form of facere "to make" (from PIE root *dhe- "to set, put").
active word-forming element in English and in many verbs inherited from French and Latin, from Latin de "down, down from, from, off; concerning" (see de), also used as a prefix in Latin, usually meaning "down, off, away, from among, down from," but also "down to the bottom, totally" hence "completely" (intensive or completive), which is its sense in many English words.
As a Latin prefix it also had the function of undoing or reversing a verb's action, and hence it came to be used as a pure privative — "not, do the opposite of, undo" — which is its primary function as a living prefix in English, as in defrost (1895), defuse (1943), de-escalate (1964), etc. In some cases, a reduced form of dis-.
word-forming element meaning "cold, characterized by cold, capable of enduring low temperatures," from Latinized form of Greek psykhros "cold," from psykhrein "blow, make cool or cold," which is perhaps from the same root as yielded psyche.
before vowels phyl-, modern word-forming element, mostly in the sciences, often meaning "phylum," from Greek phylon, phylē "a tribe," also a political subdivision in ancient Athens, from base of phyein "to bring forth, produce, make to grow," whence also physis "nature" (from PIE root *bheue- "to be, exist, grow").