late 15c. (Caxton), "destroy or derange the order of, throw into confusion," from dis- "not" (see dis-) + order (v.). Replaced earlier disordeine (mid-14c.), from Old French desordainer, from Medieval Latin disordinare "throw into disorder," from Latin dis- + ordinare "to order, regulate," from ordo (genitive ordinis) "row, rank, series, arrangement" (see order (n.)). Related: Disordered; disordering.
1520s, "lack of regular arrangement;" 1530s, "tumult, disturbance of the peace;" from disorder (v.). Meaning "an ailment, a disturbance of the body or mind" is by 1704.
"to make untidy, put in a state of disorder," 1837, American English, probably a variant of mess in its sense of "to disorder." It was attested earlier (1830) as a noun meaning "disturbance, state of confusion." Related: Mussed; mussing.
"chaotic, disorderly," 1961, apparently from shamble in the sense "disorder" (see shambles), perhaps on model of symbolic.
late 13c., "mental distress, emotional disorder of the mind, grief," from Old French destorbance (12c., Old North French distorbance), from destourber, from Latin disturbare "throw into disorder," from dis- "completely" (see dis-) + turbare "to disorder, disturb," from turba "turmoil" (see turbid).
Meaning "public disturbance, political agitation" is from c. 1300; that of "violent interruption of peace or unity" is late 14c.; it is the sense in disturbance of the (king's) peace," early 15c.
"state of being disordered or ruffled," hence "agitation, perturbation," 1813 (carfuffle), first attested in Scottish writers, from a verb meaning "to disorder, dishevel" (1580s), of obscure origin, probably from a dialect word based on Scottish verb fuffle "to throw into disorder" (1530s). The first element is perhaps as in kersplash, etc. (see ker-); OED points rather to a Gaelic car "twist, bend, turn about".