1540s, earlier sinthoma (late 14c.), from Medieval Latin sinthoma "symptom of a disease," from Late Latin symptoma, from Greek symptoma (genitive symptomatos) "a happening, accident, disease," from stem of sympiptein "to befall," from syn- "together" (see syn-) + piptein "to fall," from PIE *pi-pt-, reduplicated form of root *pet- "to rush; to fly" (see petition (n.)). Spelling altered in English by influence of Middle French and Late Latin forms. Symptomatic in general sense of "indicative (of)" is from 1751.