The adverb so at the beginning of a sentence ('So I'll pay for it!'), probably of Yiddish origin, occurs frequently in conversation. [M.Pei, "Story of English," 1952]
So? as a term of dismissal is attested from 1886 (short for is that so?); so what as an exclamation of indifference dates from 1934. So-so "mediocre" is from 1520s; so-and-so is from 1596 meaning "something unspecified;" first recorded 1897 as a euphemistic term of abuse.