"chest for keeping valuables," early 15c., save, from Middle French en sauf "in safety," from sauf (see safe (adj.)). Spelling with -f- first recorded 1680s, from influence of safe (adj.).
late 13c., "uninjured, unharmed," from Old French sauf, from Latin salvus "uninjured, healthy, safe," related to salus "good health," saluber "healthful," all from PIE *solwos from root *sol- "whole" (cf. Latin solidus "solid," Sanskrit sarvah "uninjured, intact, whole," Avestan haurva- "uninjured, intact," Old Persian haruva-, Greek holos "whole"). Meaning "not exposed to danger" is attested from late 14c.; of actions, etc., "free from risk," first recorded 1580s. Safe-conduct (late 13c.) is from Old French sauf-conduit (13c.).