the modern verb is a merger of two related O.E. words. The first is rinnan, irnan (strong, intransitive, pt. ran, pp. runnen), from P.Gmc. *renwanan (cf. M.Du. runnen, O.S., O.H.G., Goth. rinnan, Ger. rinnen "to flow, run"), both from PIE *ri-ne-a-, nasalized form of base *reie- "to flow, run" (see Rhine). The sense of "cause to run" is from O.E. ærnan, earnan (weak, transitive, probably a metathesis of *rennan), from P.Gmc. *rannjanan, causative of the root *ren- "run." Of streams, etc., from c.1200; of machinery, from 1560s. Meaning "to be in charge of" is first attested 1861, originally Amer.Eng. Meaning "to seek office in an election" is from 1826, Amer.Eng. Phrase run for it "take flight" is attested from 1640s. Most figurative uses are from horseracing or hunting (cf to run (something) into the ground, 1836, Amer.Eng.), except (to feel) run down (1901) which is from clocks (in the lit. sense, 1761). To run across "meet" is attested from 1880. To run short "exhaust one's supply" is from 1752; to run out of in the same sense is from 1713.
"spell of running," mid-15c. (earlier ren, late 14c.), from run (v.). Sense of "small stream" first recorded 1580s, mostly Northern English dialect and Amer.Eng. Meaning "series or rush of demands on a bank, etc." is first recorded 1690s. Baseball sense is from 1856. Meaning "single trip by a railroad train" is from 1857. Military aircraft sense is from 1916. Meaning "total number of copies printed" is from 1909. Meaning "tear in a knitted garment" is from 1922. Phrase a run for one's money is from 1874. Run-in "quarrel, confrontation" is from 1905.