1399, from L. primus "first," from pre-Italic *prismos, superl. of Old L. pri "before," from PIE base *per- "beyond," *pro- "before" (see pre-). To prime a pump (c.1840) meant to pour water down the tube, which saturated the sucking mechanism and made it draw up water more readily. Arithmetical sense (prime number) is from 1570; prime meridian is from 1878. Priming "first coat of paint" is from 1609. Prime time originally (1503) meant "spring time;" broadcasting sense of "peak tuning-in period" is attested from 1964.
O.E. prim "earliest canonical hour" (6 a.m.), from M.L. prima "the first service," from L. prima hora "the first hour" (of the Roman day). Meaning "most vigorous stage" first recorded 1536; specifically "springtime of human life" (often meaning ages roughly 21 to 28) is from 1592.