c.1410, "injury, hurt, harm," from Anglo-Fr. nusaunce, from O.Fr. nuisance, from pp. stem of nuire "to harm," from L. nocere "to hurt" (see noxious). Sense has softened over time, to "anything obnoxious to a community" (bad smells, pests, eyesores), 1661, then "source of annoyance, something personally disagreeable" (1831). Applied to persons from 1695.