1660s, "that which causes weariness," from French fatigue "weariness," from fatiguer "to tire," from Latin fatigare, originally "to cause to break down," later, "to weary, fatigue, tire out," from pre-Latin adj. *fati-agos "driving to the point of breakdown," from Old Latin *fatis (of unknown origin, related to adv. affatim "sufficiently" and to fatisci "crack, split") + root of agere "to drive" (see act (n.)). Meaning "weariness from exertion" is from 1719.