c.1600, from Latin empiricus "a physician guided by experience," from Greek empeirikos "experienced," from empeiria "experience," from empeiros "skilled," from en "in" (see en- (2)) + peira "trial, experiment," from PIE *per- "to try, risk." Originally a school of ancient physicians who based their practice on experience rather than theory. Earlier as a noun (1540s) in reference to the sect, and earliest (1520s) in a sense "quack doctor" which was in frequent use 16c.-19c.