1718, probably from Anglo-Irish pother, since its earliest use was by Irish writers Sheridan, Swift, Sterne. Perhaps from Ir. bodhairim "I deafen." Related: Botheration (1797); bothersome (1834).
O.E. wyrgan "to strangle," from W.Gmc. *wurgijanan (cf. M.Du. worghen, Du. worgen, O.H.G. wurgen, Ger. würgen "to strangle," O.N. virgill "rope"), from PIE *wergh- "to turn" (see wring). The oldest sense was obs. in Eng. after c.1600; meaning "annoy, bother, vex," first recorded 1671, developed from that of "harass by rough or severe treatment" (1553), as of dogs or wolves attacking sheep. Meaning "to cause mental distress or trouble" is attested from 1822; intrans. sense of "to feel anxiety or mental trouble" is first recorded 1860.
1382, "affliction, calamity, evil, scourge," also "malignant disease," from M.Fr. plague, from L.L. plaga, used in Vulgate for "pestilence," from L. plaga "stroke, wound," probably from root of plangere "to strike, lament (by beating the breast)," from or cognate with Gk. (Doric) plaga "blow," from PIE *plag- "hit" (cf. O.E. flocan "to strike, beat," Goth. flokan "to bewail," Ger. fluchen, O.Fris. floka "to curse"). O.Ir. plag (gen. plaige) "plague, pestilence" is from L. Specifically in ref. to "bubonic plague" from 1601. The verb is from 1481; in the sense of "bother, annoy" it is first recorded 1594. Plaguey "vexatious" is attested from 1615.